Татьяна Павловна Молчанова,

кандидат биологических наук, исследователь, автор более 100 публикаций в области молекулярной
диагностики гемоглобинопатий на основе определения аминокислотных замен в молекуле гемоглобина и
мутаций в ДНК глобиновых генов; исследования фундаментальных основ функционирования и
стабильности гемоглобина; исследования функционирования глобиновых генов.
На её работы ссылаются в монографиях и книгах.  

Т. П. Молчанова – являлась ведущим научным сотрудником в организации и создании методической
базы молекулярной диагностики гемоглобинопатий, впервые созданной в России в 1974 году в
Институте гематологии и переливания крови Министерства здравоохранения СССР, теперь
Гематологический Научный Центр. Т. П. Молчанова неоднократно участвовала в экспедициях в
Азербайджан, Грузию, Дагестан, Среднюю Азию для проведения совместных работ по диагностике
гемоглобинопатий в этих регионах.  
Т. П. Молчанова в 1991-1998 годах работала ведущим научным сотрудником в Международном
Центре Диагностики Гемоглобинопатий всемирно известного профессора Тайтуса Хайсмана (T. H. J.
Huisman, более 800 публикаций), где разработала и сформулировала методические подходы к
молекулярной диагностике аномальных гемоглобинов человека на основе детектирования мутаций
в глобиновых гена
х
( DNA diagnosis of Human Hbs )   (клик читать Протоколы Диагностики).
Совместно с проф. Хайсманом  Т. Молчанова в 1998 году обобщила базу данных мутационного
спектра гемоглобинопатий, и сформулировала критерии для представления мутаций в глобиновых
генах в электронной базе мутаций в гемоглобинах человека
http://globin.bx.psu.
edu/html/huisman/variants/
  .

Гемоглобинопатии.
Гемоглобинопатия – наследственное заболевание крови, обусловленное мутациями в глобиновых генах
гемоглобина человека. Молекулярная диагностика гемоглобинопатий является самой разработанной
отраслью современного здравоохранения (продолжение следует).
Список основных публикаций кандидата биологических наук Т. П. Молчановой

1.   Abaturov LV, Molchanova TP, Nosova NG, Shliapnikov SV, Faizulin DA.  - The conformational dynamic of the tetramer hemoglobin molecule as revealed by
hydrogen exchange. II. Influence of the intersubunit contact splitting - Mol Biol (Mosk). 2006 May-Jun;40(3):468-81. Russian.

2. Hamasaki-Katagiri N, Molchanova T, Takeda K, Ames JB. Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers
calcium tolerance -J Biol Chem. 2004 Mar 26;279(13):12744-54.
3. Т. Молчанова. (2004) “Лермонтов Юрий Григорьевич”. Образование и общество, №4, стр.  114-118.
4. Ames,J.B., Hamasaki,N., and Molchanova,T. (2002). Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.
Biochemistry 41, 5776-5787.

5. Molchanova,T.P., Kolledey,S.V., Pronina,L.C., Mirgorodskaya,O.A., Musolyamov,A.C., Abaturov,L.V., and Huisman,T.H. (1999). Unstable Hb Newcastle
[beta92(F8)His-->Pro], first case discovered in a Russian patient. Hemoglobin 23, 373-378.
6. Molchanova,T.P., Postnikov,Y., V, Gu,L.H., and Huisman,T.H. (1998). Historical note: the beta-thalassemia allele in the noble Russian family Lermontov is
identified as the ATG-->ACG change in the initiation codon. Hemoglobin 22, 283-286.
7. Chui,D.H., Hardison,R., Riemer,C., Miller,W., Carver,M.F., Molchanova,T.P., Efremov,G.D., and Huisman,T.H. (1998). An electronic database of human
hemoglobin variants on the World Wide Web. Blood 91, 2643-2644.
8. Hardison,R.C., Chui,D.H., Riemer,C.R., Miller,W., Carver,M.F., Molchanova,T.P., Efremov,G.D., and Huisman,T.H. (1998). Access to a syllabus of human
hemoglobin variants (1996) via the World Wide Web. Hemoglobin 22, 113-127.
9. Bisse,E., Schlemer,E., Lizama,M., Huaman-Guillen,P., Wieland,H., Adam,G., Molchanova,T.P., and Huisman,T.H. (1998). Hb Strasbourg [beta 23(B5)Val--
>Asp]; a high oxygen affinity variant observed in a German family. Hemoglobin 22, 69-73.
10. Smetanina,N.S., Molchanova,T.P., and Huisman,T.H. (1997). Analysis of mRNA from red cells of patients with thalassemia and hemoglobin variants.
Hemoglobin 21, 437-467.
11. Molchanova,T.P. and Huisman,T.H. (1997). The levels of abnormal hemoglobin in persons with heterozygosities for an alpha chain variant and for beta-
thalassemia. Hemoglobin 21, 173-177.
12. Molchanova,T.P. and Huisman,T.H. (1996). The importance of the 3' untranslated region for the expression of the alpha-globin genes. Hemoglobin 20, 41-
54.
13. Molchanova,T.P., Smetanina,N.S., and Huisman,T.H. (1995). A second, elongated, alpha 2-globin mRNA is present in reticulocytes from normal persons
and subjects with terminating codon or poly A mutations. Biochem. Biophys. Res. Commun. 214, 1184-1190.
14. Harthoorn-Lasthuizen,E.J., Nabben,F.A., Kazanetz,E.G., Gu,L.H., Molchanova,T.P., and Huisman,T.H. (1995). HB Mizuho or alpha 2 beta 2 68(E12)Leu--
>Pro in a young Dutch boy. Hemoglobin 19, 203-206.
15. Prchal,J.T., Adler,B., Wilson,J.B., Baysal,E., Qin,W.B., Molchanova,T.P., Pobedimskaya,D.D., Kazanetz,E.G., and Huisman,T.H. (1995). Hb Bibba or alpha
2 136(H19)Leu-->Pro beta 2 in a Caucasian family from Alabama. Hemoglobin 19, 151-164.
16. Pobedimskaya,D.D., Molchanova,T.P., Streichman,S., and Huisman,T.H. (1994). Compound heterozygosity for two alpha-globin gene defects, Hb Taybe
(alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-- >AATAAG), results in a severe hemolytic anemia. Am. J. Hematol. 47, 198-202.
17. Molchanova,T.P., Pobedimskaya,D.D., and Huisman,T.H. (1994). The differences in quantities of alp. Br. J. Haematol. 88, 300-306.
18. Pobedimskaya,D.D., Molchanova,T.P., and Huisman,T.H. (1994). Hb Ramona or alpha (2)24(B5)Tyr-->Cys beta 2. Hemoglobin 18, 365-366.
19. Qin,W.B., Pobedimskaya,D.D., Molchanova,T.P., Wilson,J.B., Gu,L.H., de Pablos,J.M., and Huisman,T.H. (1994). Hb Fannin-Lubbock in five Spanish
families is characterized by two mutations: beta 111 GTC-->CTC (Val-->Leu) and beta 119 GGC-->GAC (Gly-- >Asp). Hemoglobin 18, 297-306.
20. Curuk,M.A., Molchanova,T.P., Postnikov,Y., Pobedimskaya,D.D., Liang,R., Baysal,E., Kolodey,S., Smetanina,N.S., Tokarev,Y., Rumyantsev,A.G., and .
(1994). Beta-thalassemia alleles and unstable hemoglobin types among Russian pediatric patients. Am. J. Hematol. 46, 329-332.
21. Molchanova,T.P., Pobedimskaya,D.D., and Postnikov,Y. (1994). A simplified procedure for sequencing amplified DNA containing the alp. Hemoglobin 18,
251-255.
22. Molchanova,T.P., Pobedimskaya,D.D., Ye,Z., and Huisman,T.H. (1994). Two different mutations in codon 68 are observed in Hb G-Philadelphia
heterozygotes. Am. J. Hematol. 45, 345-346.
23. Qin,W.B., Baysal,E., Wong,K.F., Molchanova,T.P., Pobedimskaya,D.D., Sharma,S., Wilson,J.B., and Huisman,T.H. (1994). Quantities of alpha Q chain
variants in heterozygotes with and without a concomitant beta-thalassemia trait. Am. J. Hematol. 45, 91-93.
24. Dincol,G., Dincol,K., Erdem,S., Pobedimskaya,D.D., Molchanova,T.P., Ye,Z., Webber,B.B., Wilson,J.B., and Huisman,T.H. (1994). Hb Capa or alpha (2)94
(G1)Asp-->Gly beta 2, a mildly unstable variant with an A-->G (GAC-->GGC) mutation in codon 94 of the alpha 1-globin gene. Hemoglobin 18 , 57-60.
25. Curuk,M.A., Dimovski,A.J., Baysal,E., Gu,L.H., Kutlar,F., Molchanova,T.P., Webber,B.B., Altay,C., Gurgey,A., and Huisman,T.H. (1993). Hb Adana or alpha
2(59)(E8)Gly-->Asp beta 2, a severely unstable alpha 1-globin variant, observed in combination with the -(alpha)20.5 Kb alpha-thal-1 deletion in two Turkish
patients. Am. J. Hematol. 44, 270-275.
26. Pobedimskaya,D.D., Molchanova,T.P., Huisman,T.H., Harding,S.R., and Bakanec,R. (1993). Hb F-Saskatoon or alpha 2G gamma (2)21(B3)Glu-->Lys
observed in a North American Indian newborn. Hemoglobin 17, 547-549.
27. Pobedimskaya,D.D., Molchanova,T.P., Amernick,R., Druskin,M.S., Webber,B.B., Wilson,J.B., and Huisman,T.H. (1993). Hb Sinai-Baltimore or alpha 2 beta
(2)18(A15)Val->Gly, a silent, mildly unstable beta chain variant detected by isoelectrofocusing and high performance liquid chromatography. Hemoglobin 17,
505-512.
28. Qin,W.B., Ju,T.L., Yue,X.L., Yan,X.L., Qin,L.Y., Molchanova,T.P., Pobedimskaya,D.D., and Huisman,T.H. (1993). Hb A2-liangcheng [delta 117(G19)Asn-
>Asp(AAC->GAC)]: a new delta chain variant detected by gene analysis in a Chinese family. Hemoglobin 17, 463-466.
29. Malcorra-Azpiazu,J.J., Wilson,J.B., Molchanova,T.P., Pobedimskaya,D.D., and Huisman,T.H. (1993). Hb Porto Alegre or alpha 2 beta 29(A6)Ser->Cys in
unrelated families of the Canary Islands. Hemoglobin 17, 457-461.
30-. Postnikov,Y., Molchanova,T.P., and Huisman,T.H. (1993). Allele-specific amplification for the identification of several hemoglobin variants. Hemoglobin 17,
439-452.
31. Gu,L.H., Wilson,J.B., Molchanova,T.P., McKie,K.M., McKie,V.C., and Huisman,T.H. (1993). Three sickle cell anemia patients each with a different alpha
chain variant. Diagnostic complications. Hemoglobin 17 , 295-301.
32. Divoky,V., Svobodova,M., Indrak,K., Chrobak,L., Molchanova,T.P., and Huisman,T.H. (1993). Hb Hradec Kralove (Hb HK) or alpha 2 beta 2 115(G17)Ala--
>Asp, a severely unstable hemoglobin variant resulting in a dominant beta- thalassemia trait in a Czech family. Hemoglobin 17, 319-328.
33. Molchanova,T.P., Postnikov,Y.V., Gu,L.H., and Huisman,T.H. (1993). Hb A2-Grovetown or alpha 2 delta (2)75(E19)Leu-->Val. Hemoglobin 17, 289-291.
34. Molchanova,T.P., Postnikov,Y., Wilson,J.B., Webber,B.B., Gu,L.H., Sabio,H., Waldron,P., and Huisman,T.H. (1993). Hb Madrid or alpha 2 beta (2)115(G17)
Ala-->Pro in a black teenager. Hemoglobin 17, 251-254.
35. Molchanova,T.P., Postnikov,Y., Gu,L.H., Prior,J.F., Raven,J.L., Bennett,J.A., and Huisman,T.H. (1993). Hb Tigraye or alpha 2 beta (2)79(EF3)Asp-->His
(GAC-->CAC): a hemoglobin variant with increased oxygen affinity observed in an Ethiopian male. Hemoglobin 17, 247-250.
36. Molchanova,T.P., Postnikov,Y., Pobedimskaya,D.D., Smetanina,N.S., Moschan,A.A., Kazanetz,E.G., Tokarev,Y., and Huisman,T.H. (1993). Hb Alesha or
alpha 2 beta (2)67(E11)Val-->Met: a new unstable hemoglobin variant identified through sequencing of amplified DNA. Hemoglobin 17, 217-225.
37. Pobedimskaya,D.D., Molchanova,T.P., Gu,L.H., Molina,M.A., de Pablos,J.M., and Huisman,T.H. (1993). Hb F-Sacromonte or alpha 2G gamma (2)59(E3)
Lys-->Gln observed in a Spanish newborn and his mother. Hemoglobin 17, 269-274.
38. Molchanova,T.P. (1993). A new screening test for unstable hemoglobins using N-butanol and red blood cells. Hemoglobin 17, 81-84.
39. Smetanina,N.S., Zhestkova,N.M., Molchanova,T.P., and Tokarev,I. (1993). [Koln hemoglobinopathy: 3 patients in one Russian family]. Ter. Arkh. 65, 45-48.
40. Molchanova,T.P., Wilson,J.B., Gu,L.H., Guemira,F., Fattoum,S., and Huisman,T.H. (1992). Hb Bab-Saadoun or alpha 2 beta (2)48(CD7)Leu----Pro, a mildly
unstable variant found in an Arabian boy from Tunisia. Hemoglobin 16, 267-273.
41. Negri,A.S., Maldonado Eloy-Garcia,J., Molchanova,T.P., Wilson,J.B., Gu,L.H., and Huisman,T.H. (1992). Hb Brockton [alpha 2 beta 2(138)(H16)Ala-->Pro]
observed in a Spanish girl. Hemoglobin 16, 511-514.
42. Liu,J.S., Molchanova,T.P., Gu,L.H., Wilson,J.B., Hopmeier,P., Schnedl,W., Balaun,E., Krejs,G.J., and Huisman,T.H. (1992). Hb Graz or alpha 2 beta 2(2)
(NA2)His-->Leu; a new beta chain variant observed in four families from southern Austria. Hemoglobin 16, 493-501.
43. Molchanova,T.P., Wilson,J.B., Gu,L.H., Hain,R.D., Chang,L.S., Poon,A.O., and Huisman,T.H. (1992). A second observation of the fetal methemoglobin
variant Hb F-M-Fort Ripley or alpha 2G gamma 2(92)(F8)His----Tyr. Hemoglobin 16, 389-398.
44. Dmitrieva,M.G., Kazanets,E.G., Molchanova,T.P., Karpova,I.V., Sevast'ianova,M.G., and Andreeva,A.P. (1991). [Oxygen-binding properties of blood in
hemoglobinosis M Boston detected in the USSR for the first time]. Gematol. Transfuziol. 36, 9-11.
45. Molchanova,T.P., Kolodei,S.V., and Tokarev,Y. (1991). Expression of human membrane proteins 4.1a and 4.1b in reticulocytes and mature erythrocytes.
Biomed. Sci. 2, 379-384.
46. Tasheva,E.S., Zareva,Z.Z., Topuzova,S.T., and Molchanova,T.P. (1990). Hb Andrew-Minneapolis [beta 144(HC1)Lys----Asn] in a Bulgarian family.
Hemoglobin 14, 227-228.
47. Molchanova,T.P. (1989). [Basis of the molecular organization of erythrocyte membrane proteins and their defects leading to hemolytic anemia]. Gematol.
Transfuziol. 34, 32-41.
48. Molchanova,T.P., Mirgorodskaia,O.A., Abaturov,L.V., Podtelezhnikov,A.V., and Tokarev,I. (1989). [Location of amino acid substitutions in human
hemoglobin. Mass spectrometric rapid analysis of tryptic peptides]. Mol. Biol. (Mosk) 23, 225-239.
49. Molchanova,T.P. (1989). [Detection of unstable hemoglobins with the use of normal butyl alcohol]. Lab Delo 29-31.
50. Molchanova,T.P. and Tokarev,I. (1988). [Effect of various factors on the destruction of abnormal hemoglobins in vitro. A screening method for the detection
of unstable abnormal human hemoglobins]. Gematol. Transfuziol. 33, 39-43.
51. Kazanets,E.G., Andreeva,A.P., Molchanova,T.P., Pronina,L.K., and Tokarev,I. (1988). [First cases of the detection of Hb Hyde Park in the Soviet Union].
Gematol. Transfuziol. 33, 43-46.
52. Idel'son,L.I., Molchanova,T.P., Aseeva,E.A., Spivak,V.A., and Tokarev,I. (1987). [A second case of an Hb Takoma carrier in Moscow]. Gematol. Transfuziol.
32, 45-46.
53. Molchanova,T.P., Zareva,Z.Z., Rashkov,R.G., Abaturov,L.V., and Tokarev,I. (1987). [A first case of Hb J Paris-1 alpha2[A10] Ala----Asp beta2 carrier in
Bulgaria. Structural organization]. Gematol. Transfuziol. 32, 15-19.
54. Molchanova,T.P. (1987). [Functional role of proteolysis in erythroid cells in hemoglobinopathies]. Gematol. Transfuziol. 32, 33-39.
55. Molchanova,T.P. (1986). [Improved methods for the laboratory diagnosis of unstable human hemoglobin anomalies]. Gematol. Transfuziol. 31, 43-45.
56. Dubrova,I., Ikramov,K.M., Altukhov,I., Spivak,V.A., and Molchanova,T.P. (1985). [Genetic and clinical study of a family with abnormal hemoglobin Hb D
Punjab 121 beta Glu----Gln]. Genetika 21, 1918-1920.
57. Molchanova,T.P., Malozemova,N.G., and Abaturov,L.V. (1982). [Proteolytic degradation of native hemoglobin and its constituent parts- -isolated subunits
and globin. I. Kinetic data and the character of the process of the breakdown of native forms]. Mol. Biol. (Mosk) 16, 1128-1143.
58. Abaturov,L.A. and Molchanova,T.P. (1982). [Proteolytic degradation of native hemoglobin and its constituent parts- -isolated subunits and globin. II.
Correlation with the hydrogen exchange data and the mechanism of the burst-like proteolytic breakdown of native proteins]. Mol. Biol. (Mosk) 16, 1144-1164.
597. Spivak,V.A., Molchanova,T.P., Ermakov,N.V., Postnikov,I., and Tokarev,I. (1982). [Hemoglobin Lepore Boston in Bulgaria]. Probl. Gematol. Pereliv. Krovi.
27, 27-31.
60. Spivak,V.A., Molchanova,T.P., Postnikov,Y., Aseeva,E.A., Lutsenko,I.N., and Tokarev,Y. (1982). A new abnormal hemoglobin: Hb Mozhaisk beta 92(F8)His
leads to Arg. Hemoglobin 6, 169-181.
61. Spivak,V.A., Molchanova,T.P., Ermakov,N.V., Tokarev,Y., Martinez,G., Szelenyi,J., Horanyi,M., Foldi,J., Hollan,S., Kazieva,H., and Shamov,I.A. (1981). A
new hemoglobin variant: Hb Dagestan alpha 60(E9) Lys leads to Glu. Hemoglobin 5, 133-138.
62. Molchanova,T.P., Abaturov,L.V., Spivak,V.A., Ermakov,N.V., and Tokarev,I. (1980). [Hemoglobin M Saskatoon alpha 2 beta 2 63 (E7) His--Tyr. Structural
identification, hemichrome formation and proteolytic degradation]. Mol. Biol. (Mosk) 14, 1253-1266.
63. Spivak,V.A., Molchanova,T.P., and Tokarev,I. (1980). [Rapid and highly sensitive method of detection of abnormal hemoglobins S, E and D Punjab]. Probl.
Gematol. Pereliv. Krovi. 25, 55-59.
64. Spivak,V.A., Molchanova,T.P., Ermakov,N.V., Tokarev,I., and Gar'kavtseva,R.F. (1979). [Primary structure of abnormal E-like hemoglobin]. Biokhimiia. 44,
816-821.
65. Spivak,V.A., Molchanova,T.P., Ermakov,N.V., Tokarev,I., Gar'kavtseva,R.F., and Asanov,I. (1978). [Determination of a primary structure of abnormal D-like
hemoglobin isolated from a blood donor]. Biokhimiia. 43, 1175-1183.
66. Abaturov,L.V., Yakobashvily,N.N., Jinoria,K.S., Molchanova,T.P., and Varshavsky,Y.M. (1976). Effect of inter-subunit contact on intramolecular
conformational motility (conformational stability) of hemoglobin as revealed by hydrogen exchange. FEBS Lett. 70, 127-130.
BOOKS:
Smetanina NS, Molchanova TP, Pobedimskaya DD, Kazanezh EG, Tokarev Yu.N., Rumyantsev AG: Molecular-Genetic of the Hemoglobinopathies from
children. Practical Recommendations and Protocols for Diagnosis, 2001, Russian Ministry of Health
Abaturov L.V., Lebedev Yu.O., Molchanova T.P. et al.: Conformational rigidity and fluctuational motility of the global proteins: water as a stabilizer and
plastificator of structure. - In the Book "Equilibrium Dynamics of the Biopolymer Structure", Pushino, Russia, 1990, pp.49-77 (in Russian).
Abaturov L.V., Molchanova T.P.: Dynamic structure of proteins according to the data of the hydrogen exchange and proteolytic degradation- In the Book:"
Equilibrium Dynamics of the Native Structure of Protein", E.A. Burshtein, ed., Pushino, 1977, pp.5-25 ( in Russian).
Abstracts

Katagiri NH, Molchanova TP, Ames JB: Cloning and characterization of a fission yeast homolog of recoverin processing a calcium-myristoyl switch- Kyoto
Pombe Meeting, Japan 2002

Molchanova T.P., Smetanina N.S., and THJ Huisman : The analisis of mRNA from red cells of patients with thalassemia and hemoglobin vriants- 8-th Annual
Thalassemia Parent and Patients International Conference, Malta, April, 1997.

Hardison R.C., Reimer C., Miller W., Chui D.H.K., Molchanova T.P., Carver M.F.H., Efremov G.D., Baysal E., and T.H.J. Huisman: Electronical and printed
Syllabi describing 1 human hemoglobin variants and (2) determinants of thalassemia and HPFH – HUGO 4th International Mutation Database Meeting,
Baltimore, U.S.A., October, 1997.

Molchanova T.P., and T.H.J. Huisman: Human hemoglobin variants: a gene spesific database-HUGO Mutation Database MeetingSan Francisco, October,
1996

Molchanova, T.P., Kolodey, S.V., Tokarev, Yu.N.: Human erythrocyte membrane proteins 4.1a and 4.1b in terminal stages of erythropoiesis. Abst. Symp.
Molecular Factors of Hematopoiesis and Stem Cells, Moscow, 1990, p. 76.

Molchanova T.P., Mirgorodskaya O.A., Surin V.L. et al.: Mass-spectrometry and polymerase chain reaction in the human abnormal hemoglobin identification. -
1st All-Union Symposium on Human Genome, Pereslavl-Zalevski, Russia, 1990, pp. 174-175.

Abaturov L.V., Lebedev Yu.o., Molchanova T.P. et al. : The conformational mobility and flexibility of the protein structure. The role of the hydration in the protein
structural mobility. - 14th International Congress of Biochemistry, Prague, Czechoslovakia, 1988.

Molchanova T.P., Abaturov L.V.: The influence of the point amino acid substitution in the active center of the human hemoglobin on the Hb's conformational
stability and on Hb's affinity to the external ligands.- VI Conference on Spectroscopy of the Biopolymers, Kharkov, 1988.

Molchanova T.P., Mirgorodskaya O.A., Eremiyantz A.R. et al.: First case of carrier of unstable hemoglobin Hb Louisville b 42 (CD1) Phe-->Leu in two carriers
from Moscow family.- Belorussian Congress of Hematologists and Transfuziologists, Minsk, 1988

Molchanova T.P., Tokarev Yu.N., Murgorodskaya O.A. et al. : Mass-spectrometric express analysis of the tyiptic peptides of human hemoglobin.- VII All-Union
Symposium on Chemistry of Proteins and Peptides, Riga, 1987.

Molchanova T.P., Abaturov L.V., Tokarev Yu.N.: Role of the substitution of the external residues in the conformational stability of human hemoglobin-
Symposium on Phisico-chemical Properties of the Biopolimers in Solutions and Cells with the participation of the contries of the Council for Mutual Economic
Aid, Pushino, Russia, 1986, p. 113-114.

Molchanova T.P., Abaturov L.V., Tasheva E.S., Tokarev Yu.N.: Increased thermal denaturation of the metform of Hb O Arab ? 121 (GH4) Glu-->Lys - II National
Congress on Medical Biology and Genetics, Sofia, 1985, p.76.

Spivak V.A., Molchanova T.P., Aseeva E.A., Luztenko I.N., Postnikov Yu.V. : Molecular diagnosis and physico-chemical studies of the human abnormal
hemoglobins. - 2nd All-Union Symposium of Hematologists and Transfuziologists, L'vov, 1985, pp. 357-358.


Molchanova T.P., Spivak V.A., Tokarev Yu.N. : The study of the proteolytic degradation of the human abnormal hemoglobins. - 6th All-Union Symposium on
Chemistry of Proteins and Peptides, Riga, 1983, pp.139-140

Spivak V.A., Molchanova T.P., Aseeva E.A., Postnikov Yu.V. et al.: Studies of the influence of the amino acid substitution on the structure and clinical
manifestation of the human abnormal hemoglobins. - 6th All-Union Symposium on Chemistry of Proteins and Peptides, Riga, 1983, pp.137-138.

Spivak V.A., Molchanova T.P., Aseeva E.A., Postnikov Yu.V. et al. : Electroporesis and chromatography in studies of human abnormal hemoglobins. - 6th All-
Union Symposium on Chemistry of Proteins and Peptides, Riga, 1983, p.138.

Molchanova T.P., Spivak V.A. : The application of the ion exchange chromatography for the abnormal hemoglobin studies. - 6th All-Union Symposium on
Chemistry of Proteins and Peptides, Riga, 1983, p.129

Spivak V.A., Molchanova T.P., Postnikov Yu.V. et al.: Molecular diagnosis of the hemoglobin Buenos Aires ? 85 (F1) Phe-->Ser and studies of its properties. -
55th Scientific conference of the All-Union Hematological Scientific Center, Moscow, 1983, pp. 76-78.


Molchanova T.P., Abaturov L.V. : The mechanism of the burst-like proteolytic degradation of the native proteins. - All-Union Biophysical Congress, Moscow,
1982, p. 156.

Nosova N.G., Molchanova T.P., Abaturov L.V. : The influence of the media on the conformational and dynamic structure of the hemoglobin. - All-Union
Biophysical Congress, Moscow, 1982, pp.117-118.

Spivak V.A., Molchanova T.P., Postnikov Yu.V. et al. : Molecular diagnosis of abnormal hemoglobins. - 53d Scientific conference of the All-Union Hematological
Scientific Center, Moscow, 1981, p. 115.

Tokarev Yu.N., Kolodey S.V., Postnikov Yu.V., Molchanova T.P. et al.: Distribution and heterogenety of the hereditary hemoglobinopathies in some regions of
the Central Asia and Caucases. - 53d Scientific conference of the All-Union Hematological Scientific Center, Moscow, 1981, p. 101.

Abaturov L.V., Molchanova T.P., Dzinoria K.Sh., Lebedev Yu.O., Yakobashvili N.N.: Dynamic model of the global protein structure - All-Union Symposium on
Macromoleculars of Cell. Structure, Function, Interactions, Moscow, 1979, p. 44.

Spivak V.A., Molchanova T.P., Ermakov N.V., Tokarev Yu.N. : Study of the primary structure of abnormal hemoglobins. - 1st All-Union Symposium of
Hematologists and Transfuziologists, Baku, 1979, p. 205.

5. Abaturov L.V., Molchanova T.P., Dzinoria K.Sh., Lebedev Yu.O., Yakobashvili N.N.: Dynamic model of the global protein structure - All-Union Symposium on
Macromoleculars of Cell. Structure, Function, Interactions, Moscow, 1979, p. 44.

6. Spivak V.A., Molchanova T.P., Ermakov N.V., Tokarev Yu.N. : Study of the primary structure of abnormal hemoglobins. - 1st All-Union Symposium of
Hematologists and Transfuziologists, Baku, 1979, p. 205.

Molchanova T.P., Spivak V.A., Abaturov L.V. et al.: Hemoglobin M Saskatoon, molecular diagnosis, hemichrome formation and proteolytic degradation. - 1st
All-Union Symposium of Hematologists and Transfuziologists, Baku, 1979, p. 218.


Abaturov L.V., Molchanova T.P.: The connection between genetics and conformational stability of human abhormal hemoglobins. - All-Union Conference on the
Mechanisms of Regulation in the Blood System, Krasnoyarsk, Russia, 1978, pp. 127-128.

Abaturov L.V., Molchanova T.P.: The fewer number of detected alpha chain point mutations in comparison with beta chain mutants of human hemoglobins as a
result of the difference in conformational stability of normal chains- XIV International Congress of Genetics, Moscow, 1978, part 1, p. 25.

Spivak V.A., Molchanova T.P., Ermakov N.V. et al. : Determination of the primary structure of the D-like abnormal hemoglobin found in donor blood. - 1st
Republican Conference on Hemolytic Anemias, Dushanbe, 1976, pp. 111-112.

Abaturov L.V., Molchanova T.P., Dzinoria K.Sh. et al. : Intramolecular mobility different ligand forms of human hemoglobin, its constituent pats: globin and
sibunits according to the data of the hydrogen exchange and proteolytic degradation. - XI Mendeleev Symposium on General and Applied Chemistry, Almaata,
1975, p.40.

Molchanova T.P., Malozemova H.G., Abaturov L.V. : Ptoteolytic degradation of the hemoglobin and its constituent parts. - Conference on Conformational
Changes of Biopolymers in Solutions, Tbilisi, 1975, pp.113-114.


Molchanova T.P., Tatishvili D.A., Abaturov L.V., Varshavski Ya.M. : Some structural features of the hemichromes as an intermediate form in the course of
denaturation and spontneouse inactivation of hemoglobin. - Soviet-French Symposium on the Physical Chemistry of Proteins and Peptides, Pushino, Russia,
1975, p.38.

Abaturov L.V., Yakobashvily N.N., Jinoriya K.Sh., Molchanova T.P., Varshavsky Ya.M.: Effect of inter-subunit contact on intramolecular conformational motility
(conformational stability) of hemoglobin as related by hydrogen exchange- Abst.Commun. 9th FEBS Meeting, Budapest, 1974, p.350


REVIEWS:
Molchanova T.P., T.H.J. Huisman - Hemoglobinopathies in Russia. Review (former USSR), Balkan J. Med. Gen., 1 (4), 143-148, 1998.
Molchanova, T.P., Postnikov, Yu.V.: Hemoglobinopathies in the former Soviet Union (Review). Sphere, 15(3): 1-4, 1992.
Molchanova, T.P., Tokarev, Yu.N.: Abnormal Hemoglobins in the USSR (Review). In: "Hematology Reviews" (ed. by O.K. Gavrilov), Harvard Acad. Press, v. 2B,
pp. 1-32, 1990.
Molchanova, T.P.: The basis of molecular organisation of the erythrocyte membrane proteins and their defects in hemolytic anemias (Review). - Gematol. and
Transfus., 34: 32-41, 1989 (Russian ).
Molchanova, T.P.: The functional role of proteolysis in erythroid cells (Review). Gematol. and Transfus., 32(3): 33-39, 1987 (Russian).
В 1992 году Т. Р. Молчанова и Ю. В. Постников обобщили данные о распространении гемоглобинопатий: таласемии и аномальных гемоглобинов, в международном
журнале «Сфера», издаваемом в Медицинском колледже штата Джорджия (Molchanova, T.P., Postnikov, Yu.V.: Hemoglobinopathies in the former Soviet Union (Review). Sphere,
15(3): 1-4, 1992).
К 1992 году было установлено, что бета-талассемия наиболее распространена в Азербайджане. К тому времени было идентифицировано одиннадцать ДНК-мутаций в бета-
глобиновых генах в Азербайджане, среди них 50% относилось с Средиземноморскому типу, и 6% были специфичны для Азербайджана, остальные относились к Иранскому,
Курдскому, Индийскому типу мутаций. Эти очень важные статистические данные могли быть положены в основу скрининга азербайджанского население, где по современным
данным (2007) каждый 12-й является носителем гена талассемии. По распоряжению Президента Азербайджанской Республики Ильхама Алиева 10 февраля 2015 года утверждена
«Государственная программы по борьбе с талассемией на 2015-2020 годы».
Бета-Талассемия – наследственное нарушение синтеза бета-глобинового гена молекулы гемоглобина в результате мутации в бета-глобиновом гене.  
Минорная форма бета-талассемии, как результат определенной мутации в одном бета-глобиновом гене – гетерозиготная бета-талассемия, часто приводит к небольшому снижения
синтеза гемоглобина, совместимому с практически нормальной жизнедеятельностью человека.
Нарушение синтеза двух бета-глобиновых генов – гомозиготная бета-талассемия, как результат наследования двух мутантных бета-глобиновых генов от обоих родителей, носителей
гетерозиготной бета-талассемии, приводит к тяжелой форме бета-талассемии, вплоть до летального исхода.
Диагностика бета-талассемии одна из самых разработанных в мире отраслей здравоохранения.
Интересно, что несколько мировых звезд кинематографа, спорта и известной российской фамилии Лермонтов являются носителями минорной формы бета-талассемии:
Абхишек Баччан  (Abhishek Bachchan) (1976) – популярный индийский актер
Амитабх Баччан (Amitabh Bachchan (1942) – звезда индийского кинематографа